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Randomized Controlled Trials: Questions, Answers and Musings

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Randomized controlled trials are one of the most powerful and revolutionary tools of research. This book is a convenient and accessible description of the underlying principles and practice of randomized controlled trials and their role in clinical decision-making.Structured in a jargon-free question-and-answer format, each chapter provides concise and understandable information on a different aspect of randomized controlled trials, from the basics of trial design and terminology to the interpretation of results and their use in driving evidence-based medicine. The authors end each chapter with their musings, going beyond the evidence or citations, and sometimes even beyond orthodox correctness to share their thoughts and concerns about different aspects of randomized controlled trials, and their role within the health system.Updated to include insights from the last decade, this second edition challenges over-reliance on randomized controlled trials by debating their strengths and limitations and discussing their optimal use in modern healthcare. It also includes a new and increasingly relevant chapter on the ethics of randomized trials.World renowned writers and thinkers Drs Jadad and Enkin bring you this invaluable book for busy health professionals who wish to understand the theory of randomized controlled trials and their influence on clinical, research or policy decisions.

160 pages, Kindle Edition

First published July 23, 2007

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About the author

Alejandro Alex Jadad

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Profile Image for Amie.
332 reviews5 followers
November 6, 2024
This book offers a comprehensive exploration of RCTs, including their design, analysis, and interpretation. I particularly enjoyed the focus on critical appraisal tools during the assessment phase and found this useful in framing my understanding.

Unsurprisingly much of the book was focused around health / clinical trials but the way Jadad had written it, it made it really straightforward to assess in other settings (by way of nudges in consumer behaviour). The author effectively highlights the importance of the evaluation stage in RCTs, providing detailed insights into how to critically assess trials. Its practical approach makes it especially valuable for anyone looking to deepen their understanding of RCT methodology and rigour in trial assessments.
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